You can associate one hazardous materials commodity with each FedEx Ground package. Each HazMat package must be processed as a single package.
To process a HazMat shipment:
While processing a shipment with The Eagle, select the Package Options tab.
Enable the Hazardous check box.
In the Profile field, select a HazMat Profile
ID from the drop-down list.
To add a new hazardous material for this shipment
You may also press the " ... " button beside the Profile field to enter information for a new hazardous material. The new hazardous material will be maintained for this shipment only. To permanently add an entry to the hazardous materials database from here, you can click the " ... " button next to the HazMat Profile ID to access Hazardous Materials Profile Maintenance.
Click OK when you are done.

The information for that hazardous material populates the tab.
Press Save or F5 to save the shipment.
Notes:
Hazardous shipments cannot be used in conjunction with the Return Label option.
You can process hazardous shipments with both FedEx solutions: Basic (Internet) and High Volume. The difference is that with High Volume, the HazMat documentation will be printed for you. With FedEx Internet, the HazMat documentation will not. You must generate the documentation.
Additional Info:
FedEx Hazardous Materials Profile Maintenance
FedEx.com - Dangerous Goods Info